Increased Encapsulation Efficiency of Methotrexate in Liposomes for Rheumatoid Arthritis Therapy
نویسندگان
چکیده
منابع مشابه
Adherence to Methotrexate therapy in Rheumatoid Arthritis
OBJECTIVE To determine adherence to methotrexate (MTX) therapy in patients with Rheumatoid Arthritis (RA) and to identify factors that promote either adherence or non adherence. METHODS One hundred Rheumatoid Arthritis patients on MTX for at least two months were enrolled. Questionnaire was completed by direct interview. Details recorded were, demographics (age, sex, education, monthly income...
متن کاملBeyond methotrexate: biologic therapy in rheumatoid arthritis.
Biologics have revolutionised the treatment of RA due to their efficacy, speed of onset and tolerability. Increasing evidence suggests that early intervention is the key to combating RA. The future challenge is to find the best time to introduce biologics into the treatment paradigm in the hope of inducing disease remission--something unthinkable even a decade ago.
متن کاملLiver Toxicity in Rheumatoid Arthritis Patients Treated With Methotrexate
Background:Methotrexate (MTX) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (RA) which can be associated with toxic effects on different organs. This study was designed to investigate the hepatotoxic effects in RA patients treated with MTX. Methods: In this cross-sectional observational study, RA patients who received standard d...
متن کاملMethotrexate in rheumatoid arthritis.
A variety of disease-modifying antirheumatic drugs (DMARDs) are available to control the clinical activity of rheumatoid arthritis (RA). Methotrexate (MTX), an analogue of folic acid and of aminopterin, is the most commonly used DMARD and is now prescribed worldwide to at least 500,000 patients with RA. The mechanism by which MTX used at a low dose modulates inflammation in RA is still unknown....
متن کاملFolate supplementation during methotrexate therapy for rheumatoid arthritis.
Methotrexate (MTX), an antifolate, is an anchor drug for the treatment of rheumatoid arthritis (RA). Both folic acid (FA) and folinic acid (FLN) supplements have been shown to reduce the toxicity of MTX when used in RA therapy. The effect of folate supplementation on MTX efficacy still needs to be studied. FA supplementation has been found to have a beneficial effect on homocysteine (hcy) metab...
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2020
ISSN: 2227-9059
DOI: 10.3390/biomedicines8120630